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1 Department of Pharmacology, University of Michigan, Ann Arbor
The effects of drugs with known degrees of selectivity in depressing polysynaptic pathways in the spinal cord were determined on the polysynaptic circuits involved in EEG arousal and recruitment. Arousal and recruiting responses elicited from the midbrain reticular formation and the diffuse thalamic projection system differed markedly in sensitivity to ethyl ether, pentobarbital, and mephenesin.
Presumptive evidence is presented on which is based a working hypothesis of the existence in the brain stem reticular formation of an ascending deactivating or inhibitory system.
Submitted on July 20, 1955
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