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Journal of Pharmacology And Experimental Therapeutics, Vol. 115, Issue 4, 427-431, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLISM OF RESERPINE1. I. STUDIES IN THE MOUSE WITH C-14 LABELED RESERPINE

Paul Numerof 1, Maxwell Gordon 1, and Jacques M. Kelly 1

1 Squibb Institute for Medical Research, New Brunswick, New Jersey

Reserpine, labeled with carbon-14 in the carboxyl group of the trimethoxybenzoyl moiety, has been prepared and its metabolism studied in the mouse. The drug was given at equi-effective ptotic doses of 96 micrograms/mouse orally and 6 micrograms/mouse intravenously. Reserpine, whether given orally or intravenously, is rapidly metabolized; 30-40 per cent of the dose appears in the urine as trimethoxybenzoic acid within four hours. Fecal excretion of unchanged reserpine is about 8 per cent after an oral dose of 96 micrograms and about 35 per cent after an intravenous dose of 6 micrograms.

The authors wish to express their appreciation to Dr. J. C. Burke and Dr. B. Rubin for helpful discussion during the course of this work.

Submitted on July 18, 1955






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.