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Journal of Pharmacology And Experimental Therapeutics, Vol. 115, Issue 4, 419-426, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGIC PROPERTIES OF 4-ALKOXY-beta-(1-PIPERIDYL)PROPIOPHENONES

Benedict E. Abreu 1, Alice B. Richards 1, Lawrence C. Weaver 1, George R. Burch 1, Carl A. Bunde 1, Earl R. Bockstahler 1, and Donald L. Wright 1

1 Research Department, Pitman-Moore Company, Division of Allied Laboratories, Inc., Indianapolis, Indiana

Alkoxy substitution at the 4 position of the aromatic ring in beta-(1-piperidyl)- propiophenone

a. increases:

(1) local anesthetic activity

(2) spinal internuncial neuronal depressant action

(3) depressant effects on the tremor of the canine tremor syndrome

(4) central nervous system deliriant and convulsant effects b. abolishes cholinolytic activity.

Local anesthetic potency, antitremor effectiveness and activity as a spinal internuncial neuronal depressant parallel the increase in side chain length reaching a maximum in substitutions varying from 4 to 7 carbons in length.

Submitted on July 18, 1955






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.