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Journal of Pharmacology And Experimental Therapeutics, Vol. 115, Issue 4, 413-418, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

LOCAL ANESTHETIC AND PHARMACOLOGIC PROPERTIES OF 4n-BUTOXY beta-(1-PIPERIDYL) PROPIOPHENONE HCl1 AND beta-DIETHYLAMINOETHYL p-n-HEXYLOXYBENZILATE HCl

Ram B. Arora 1 and Vishweshwar N. Sharma 1

1 Department of Pharmacology and Experimental Therapeutics, S. M. S. Medical College, Jaipur, Rajasthan

A pharmacologic comparison of a p-alkoxy substituted basic ester of benzilic acid and a p-alkoxy basic propiophenone has revealed the following: a. Both possess local anesthetic activity, the benzilic acid ester being more potent, but slower in onset of action and more irritant. b. Neither possesses cholinolytic nor cholinergic properties. c. Both depress arterial pressure partially by decreasing cardiac output and by "direct" vasodilatation.

Studies in man with 4n-butoxy beta-(1-piperidyl) propiophenone (dyclonine) indicate that it is a highly effective relatively non-irritating surface anesthetic agent, which can safely be employed in ophthalmic surgery.

Submitted on July 18, 1955






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.