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Journal of Pharmacology And Experimental Therapeutics, Vol. 115, Issue 3, 360-370, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLISM OF ETHYL ALCOHOL IN THE RAT

Albert H. Owens Jr. 1 and E. K. Marshall Jr. 1

1 Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University

In the rat, the rate of decline of the concentration of alcohol in the blood is constant, implying a constant rate of oxidation independent of the amount present. The rate of oxidation did not vary with doses of 1 and 2.5 gm. per kgm.

The rate of oxidation was influenced by diet. On a protein free diet it was decreased to about one-half and with 48 hours fasting to about one-third of the normal value.

The rate of oxidation was usually increased by injection of sodium pyruvate and DPN but similar increases occurred after injections of sodium chloride. This effect appears to be due to a discharge of the adrenal medulla.

When alcohol was given by mouth about 30 per cent remained in the gastro-intestinal tract at 1 hour. Subsequent absorption appeared to proceed at a constant rate.

Submitted on July 5, 1955






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