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Journal of Pharmacology And Experimental Therapeutics, Vol. 115, Issue 2, 211-220, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF CERTAIN TRI-SUBSTITUTED PHOSPHINE OXIDES ON SYNAPTIC CONDUCTION IN THE ROACH

Kenneth D. Roeder 1 and Nancy K. Kennedy 1

1 Department of Biology, Tufts University, Medford, Massachusetts

The effects of seven tri-substituted phosphine oxides have been studied on synaptic conduction in the last abdominal ganglion of the roach.

The most active of these is methyl-(1-methyl-2,2-dimethyl-propoxy) fluorophosphine oxide. When applied directly to the ganglion it causes synaptic instability amid after-discharge in 5.7 x 10-11M solution. This effect is irreversible and probably due to inactivation of cholinesterase.

Higher concentrations of the agent may cause a normal-appearing synchronized synaptic response and eventual synaptic block, effects which may be removed by washing with saline.

Atropine, d-tubocurarine, scopolamine amid acetyicholine have little or no effect upon these changes produced by the phosphines. The phosphines abolish the stimulating effects of nicotine on the roach nerve-cord.

The reversible effects of the phosphines on synaptic conduction could be due to competition with the mediator for the receptor.

Submitted on February 21, 1955






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.