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Journal of Pharmacology And Experimental Therapeutics, Vol. 115, Issue 1, 61-67, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF METALLIC CATIONS ON THE ANTI-STREPTOMYCES ACTIVITY OF ANHYDROCHLORTETRACYCLINE

Eugene D. Weinberg 1 and Marilyn Shifter Foley 1

1 Department of Bacteriology, Indiana University, Bloomington , Indiana

The ability of 25 multivalent ions to suppress the toxicity of anhydrochlor-tetracycline towards three species of Streptomyces was studied. Of the ions, only Fe++ was active.

The results of similar studies with oxy-, chlor-, and tetracycline in which one algal and ten bacterial species were employed are briefly reviewed. With each strain either Fe++ or Mg++ or both were the strongest drug-reversing ions. The active ions varied with the microbial species and with the type of medium employed but not with the kind of tetracycline compound.

Submitted on April 28, 1955






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