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Journal of Pharmacology And Experimental Therapeutics, Vol. 115, Issue 1, 55-60, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

ASSAY OF RESERPINE BASED ON EMESIS IN PIGEONS

Alfred E. Earl 1, Robert L. Winters 1, and Charles M. Schneider 1

1 Research Department, CIBA Pharmaceutical Products, Inc., Summit, New Jersey

Reserpine (Serpasil) administered to pigeons in parenteral doses of 0.060-0.120 mgm./kgm. of body weight produced a graded emetic response permitting its use as a qualitative and quantitative assay. The ED50 of reserpine from the combined results of eight two-dose tests was 0.0820 mgm./kgm. At P = 0.95, its confidence limits were 0.0708 and 0.0949 mgm./kgm.

The assay is not specific for reserpine since rescinnamine and deserpidine produced emesis within the same approximate dose range. Since digitalis, veratrum and quinacrine produce a comparable effect, emesis in pigeons does not indicate reserpine activity per se. This may be qualified by correlating it with the known pharmacologic effects of reserpine in other animals.

At more than 20 times the ED50 of reserpine, alkaloids and degradation products isolated from reserpine were inactive except rescinnamine and deserpidine which were effective within approximately the same dose range.

Submitted on April 18, 1955




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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.