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Journal of Pharmacology And Experimental Therapeutics, Vol. 115, Issue 1, 120-125, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF EPINEPHRINE AND RELATED AMINES ON CONTRACTION AND GLYCOGENOLYSIS OF THE RAT'S DIAPHRAGM

Sydney Ellis 1, Adrienne H. Davis 1, and Hilton L. Anderson Jr. 1

1 Department of Pharmacology, Temple Univ. School of Medicine, Philadelphia 40, Pennsylvania

The relative potencies of the sympathomimetic amines in reference to glycogenolysis in rat hemidiaphragm were as follows: isoproterenol > epinephrine >> levarterenol = phenylephrine. Ephedrine had only a slight effect on glycogenolysis.

The relative potencies of the sympathomimetic amines in reference to the improvement of contraction in potassium-depressed diaphragms were as follows: isoproterenol > epinephrine >> levarterenol = phenylephrine = ephedrine. Fundamental differences in the mode of action of ephedrine from that of the other amines are discussed.

The possible interdependence of the effect of epinephrine on glycogenolysis and on the force of contraction is discussed.

Submitted on May 9, 1955






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