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Journal of Pharmacology And Experimental Therapeutics, Vol. 114, Issue 4, 461-469, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF AMINOPHYLLINE AND MEPERIDINE ALONE AND IN COMBINATION ON THE RESPIRATORY RESPONSE TO CARBON DIOXIDE INHALATION

M. W. Stroud 1, C. J. Lambertsen 1, J. H. Ewing 1, R. H. Kough 1, R. A. Gould 1, and C. F. Schmidt 1

1 Laboratory of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

The effects of 3 and 6 mgm./kgm. of aminophylline, and of 6 mgm./kgm. of aminophylline together with 150 mgm. of meperidine, upon the respiratory response to ascending concentrations of inspired and alveolar carbon dioxide were studied in normal subjects.

At an alveolar pCO2 of 46 mm. Hg, 3 and 6 mgm./kgm. of aminophylline increased respiratory minute volume 46 and 98 per cent, respectively; tidal volume was increased by both doses, respiratory rate only by the larger dose. The administration of aminophylline with meperidine counteracted most of the respiratory depressant effects of meperidine.

Submitted on April 7, 1955






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.