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Journal of Pharmacology And Experimental Therapeutics, Vol. 114, Issue 4, 445-452, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

A SURVEY OF AGENTS PRODUCING CARDIOVASCULAR MANIFESTATIONS OF EPINEPHRINE DISCHARGE

E. F. Woods 1 and J. A. Richardson 1

1 Department of Pharmacology, Medical College of South Carolina, Charleston, S. C.

Intra-aortic injections of a wide variety of agents have been investigated with respect to their abilities to produce epinephrine discharge as judged by increments in heart force, blood pressure and heart rate.

General anesthesia markedly reduced the responsiveness of the adrenal medulla to nicotine, potassium chloride and calcium chloride.

Moderate degrees of hypoxia did not significantly influence the responses to nicotine and potassium chloride.

Submitted on April 1, 1955






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.