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1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, United States Public Health Service, Department of Health, Education, and Welfare, Bethesda, Maryland
An enzyme system in rabbit liver microsomes which catalyzes the demethylation of ephedrine to yield norephedrine and formaldehyde is described. The enzyme system requires reduced triphosphopyridine nucleotide and oxygen.
Species differences in the metabolism of ephedrine may be explained in part by differences in the activity of ephedrine-demethylating enzyme and in part by the presence of a heat labile inhibitory factor in microsomes. A heat stable factor which can stimulate the enzymatic demethylation of ephedrine is also present in microsomes.
Submitted on March 30, 1955
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