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Journal of Pharmacology And Experimental Therapeutics, Vol. 114, Issue 4, 409-417, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE ENZYMATIC METABOLISM OF HEXOBARBITAL (EVIPAL)

Jack R. Cooper 1 and Bernard B. Brodie 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland

Hexobarbital (Evipal) is oxidized in rabbit liver homogenates to yield keto-Evipal, a derivative of Evipal in which one of the methylene groups of the cyclohexenyl ring is converted to a carbonyl group. Both TPNH and oxygen are required and the oxidative system is located in the microsomes.

The oxidation of Evipal is inhibited by diethylaminoethyl diphenylpropylacetate (SKF 525-A). This compound also inhibits the oxidation of a number of other types of drugs, which are oxidized by biochemical mechanisms located in microsomes and which require oxygen and TPNH.

Submitted on March 25, 1955




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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.