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Journal of Pharmacology And Experimental Therapeutics, Vol. 114, Issue 4, 391-397, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF STRUCTURE ON THE ABILITY OF HYDRAZINO COMPOUNDS TO PRODUCE FATTY LIVERS

Allan S. Yard 1 and Herbert McKennis Jr.1

1 Department of Pharmacology, Medical College of Virginia, Richmond

A study was made of comparative ability of hydrazine, benzhydrazide, phenacet-hydrazide, L-ggr-glutamylhydrazide, carbazic acid, methylhydrazine, and meso agr, beta-diaminosuccinic acid to produce fatty livers in the fasted rabbit. Fatty infiltration was observed following administration of hydrazine, benzhydrazide, phenacethydrazide and carbazic acid. In contrast no fatty livers were obtained after administration of methylhydrazine, L-ggr-glutamylhydrazide and meso-agr, beta-diaminosuccinic acid.

Meso-agr, beta-diaminosuccinic acid, in contrast to the findings of Suzuki, Suzuki and Egami (1952) in E. coli coli was not degraded to determinable hydrazine by the rabbit. After administration of either benzhydrazide or hydrazine, hydrazino nitrogen was present in the urine. Fourteen to 21 per cent of the administered dose of the former was excreted in thirty hours. Under similar conditions 17 to 25 per cent of the administered dose of hydrazine was excreted in thirty hours.

Submitted on March 12, 1955




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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.