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Journal of Pharmacology And Experimental Therapeutics, Vol. 114, Issue 4, 381-384, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

TRICHURICIDAL ACTIVITY OF PHTHALOFYNE AND CERTAIN RELATED COMPOUNDS

Frank A. Ehrenford 1, Alice B. Richards 1, Benedict E. Abreu 1, Earl R. Bockstahler 1, Lawrence C. Weaver 1, and Carl A. Bunde 1

1 Research Department, Pitman-Moore Company, Division of Allied Laboratories, Indianapolis, Indiana

A new anthelmintic compound, phthalofyne, 3-methyl-1-pentyn-3-yl acid phthalate, was found to be specific, effective, and safe against canine Trichuris vulpis in a single oral dose.

Other esters of phthalic acid (1-pentyn-3-yl acid phthalate, di-n-butyl dithyllate, di-ethyl-phthalate) as well as methylparafynol and phthalic anhydride were not found to be effective trichuricidal agents.

Submitted on February 28, 1955






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.