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Journal of Pharmacology And Experimental Therapeutics, Vol. 114, Issue 3, 350-359, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF LEVALLORPHAN TARTRATE (LEVO-3-HYDROXY-N-ALLYLMORPHINAN TARTRATE) ON THE RESPIRATION OF RABBITS GIVEN MORPHINE

Jack W. Miller 1, Thomas M. Gilfoil 1, and F. E. Shideman 1

1 Department of Pharmacology and Toxicology, The University of Wisconsin, Service Memorial Institutes, Madison 6, Wisconsin

The results of an investigation concerning the effect of levallorphan on the respiration of rabbits given morphine have been presented. Depending on the relative and absolute doses involved, levallorphan was found to antagonize, further depress, or stimulate the respiration of morphine-treated animals. The results have been interpreted on the basis of competition for receptor sites between two pharmacologically similar agents in which the less potent agent has the greater receptor affinity.

Submitted on July 5, 1955






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.