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Journal of Pharmacology And Experimental Therapeutics, Vol. 114, Issue 3, 343-349, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

HYPOGLYCEMIC EFFECT OF MESOXALATE PRODUCED BY INFUSION INTO THE PANCREATIC CIRCULATION IN THE DOG

Yoshito Kobayashi 1 and Shigeru Ohashi 1

1 Department of Pharmacology, Faculty of Medicine, University of Tokyo, Japan

Continuous infusion of sodium mesoxalate into the pancreatic artery, via the common hepatic artery, produced hypoglycemia in dogs much more readily than did infusions into the jugular and portal veins. Substances closely related to sodium mesoxalate did not produce such an effect. The findings suggest that the hypoglycemic effect of sodium mesoxalate may be the result of an increased secretion of insulin.

Submitted on July 5, 1955






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