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1 Department of Physiology and Pharmacology, Duke University School of Medicine, Durham, North Carolina
The addition of the purine analogues, 6-mercaptopurine and 2,6-diamino-purine, and the pyrimidine analogues, 5-aminouracil, 5-methyl-2-thiouracil, 6-methyl-2-thiouracil, 2-thiocytosine, and 2-thiouracil, inhibited the formation of adaptive enzymes for the oxidation of benzoic acid in this mycobacterium. 2-Thioorotic acid had no effect.
The addition of the purine analogues, 6-mercaptopurine and 2,-diamino-purin aminthe pyrimidines, 5-aminouracil, 5-methyl-2-thiouracil, 6-methyl-2-thiouracil, and 2-thioorotic acid, inhibited the formation of the adaptive enzymes for the oxidation of myo-inositol in this mycobacterium. 2-Thiouracil had no effect.
Submitted on July 1, 1955
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