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Journal of Pharmacology And Experimental Therapeutics, Vol. 114, Issue 3, 300-304, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF REDUCED GLUTATHIONE AND RELATED SUBSTANCES ON THE THRESHOLD OF IRRITABILITY OF MAMMALIAN VENTRICULAR MUSCLE

Solomon Garb 1, Alexander Scriabine 1, Mario Penna 1, Hiroshi Fujimori 1, Ann Kirk 1, and Robert Hardy 1

1 Department of Pharmacology, Cornell University Medical College, New York City

Reduced glutathione produced a marked lowering of the threshold of irritability of the cat papillary muscle but did not change contractile force. On the other hand, methionine did not change irritability but increased contractile force. Cysteine lowered the threshold of irritability and increased contractile force. These findings suggest that different metabolic cycles may be involved in furnishing energy for the various aspects of cardiac muscle function. Reduced glutathione may prove useful in some cases of diminished ventricular irritability.

Submitted on June 27, 1955






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.