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Journal of Pharmacology And Experimental Therapeutics, Vol. 114, Issue 3, 275-282, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLISM OF BUTABARBITAL (BUTISOL) IN THE DOG

E. W. Maynert 1 and Laura Losin 1

1 Department of Pharmacology, College of Physicians and Surgeons, Columbia University, and Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University

Specific methods for the determination of butabarbital in plasma and urine are described.

Butabarbital disappears from the plasma of dogs at a rate of about 6 per cent per hour. This rate, which is intermediate between those for barbital and pentobarbital, supports the concept that the length of depressant action of a dialkylbarbiturate depends to a considerable extent upon the duration of its sojourn in the body.

Unchanged butabarbital equivalent to 3-5 per cent of the dose could be detected in the urine.

A metabolite which was proved to be 5-ethyl, 5(1-methyl, 2-carboxyethyl)- barbituric acid was isolated from urine. Two dogs excreted this compound in amounts corresponding to 28 and 35 per cent of a dose of butabarbital.

Butabarbital causes increased amounts of glucuronides to appear in urine.

Submitted on June 20, 1955






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