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Journal of Pharmacology And Experimental Therapeutics, Vol. 114, Issue 3, 259-267, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE ENZYMATIC CONVERSION OF CODEINE TO MORPHINE

Julius Axelrod 1

1 Laboratory of Clinical Biochemistry and Physiology, National Institute of Mental Health, and the Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, United States Public Health Service, Department of Health, Education, and Welfare, Bethesda, Md.

An enzyme system in liver of a number of mammalian species which catalyzes the cleavage of codeine to yield morphine and formaldehyde is described. This enzyme system is located in the microsomes and requires reduced triphosphopyridine nucleotide and oxygen.

Submitted on June 13, 1955






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