JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Heim, H. C.
Right arrow Articles by McDonald, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Heim, H. C.
Right arrow Articles by McDonald, J. G.
Journal of Pharmacology And Experimental Therapeutics, Vol. 114, Issue 1, 51-53, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF HYDROCORTISONE ON THE OXYGEN UPTAKE OF INFLAMED TISSUE

Harold C. Heim 1, Richard A. Deitrich 1, and John G. McDonald 1

1 College of Pharmacy, University of Colorado, Boulder, Colorado and Department of Medicine, University of Colorado, Medical Center, Denver

Inflammation was induced in rats by the injection of croton oil, and the Qo2, of the inflamed tissue was determined.

The addition of adenylate to the homogenates was found to increase the Qo2, The Qo2 was found to be increased after the injection of hydrocortisone into the granuloma pouches but this effect was not observed when the hydrocortisone was replaced by either desoxycorticosterone, progesterone, or cholesterol. The effects observed with hydrocortisone were not observed in vitro, but rather were observed only with homogenates prepared from the tissue from animals previously injected with hydrocortisone.

Submitted on January 11, 1955






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.