JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hess, S. M.
Right arrow Articles by Fitzhugh, O. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hess, S. M.
Right arrow Articles by Fitzhugh, O. G.
Journal of Pharmacology And Experimental Therapeutics, Vol. 114, Issue 1, 38-42, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

ABSORPTION AND EXCRETION OF CERTAIN TRIPHENYLMETHANE COLORS IN RATS AND DOGS

S. M. Hess 1 and O. G. Fitzhugh 1

1 Division of Pharmacology, Food and Drug Administration, Department of Health, Education, and Welfare

FD&C triphenylmethane colors FD&C Blue No. 1, FD&C Green No. 1, FD&C Green No. 3, and FD&C Violet No. 1, administered orally to rats, were found to be almost completely excreted in the feces. FD&C Green No. 2 was not recovered in the same quantitative yields obtained with the others, probably because of its instability in the body. None of the colors was found in the urine.

The loss of the administered color was reduced when the dose was changed from 200 to 20 mgm.

The colors were found in small amounts in the bile of dogs after the administration of moderate doses per os.

The quantity of these colors absorbed from the gastrointestinal tract after oral administration was calculated to be on the order of 10 mgm. for a 200 mgm. dose.

Submitted on January 10, 1955




This article has been cited by other articles:


Home page
 ChestHome page
M. R. Lucarelli, M. B. Shirk, M. W. Julian, and E. D. Crouser
Toxicity of Food Drug and Cosmetic Blue No. 1 Dye in Critically Ill Patients
Chest, February 1, 2004; 125(2): 793 - 795.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.