JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LOEWE, S.
Right arrow Articles by PERKINS, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LOEWE, S.
Right arrow Articles by PERKINS, W.
Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 4, 475-480, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

ISOBOLS OF DOSE-EFFECT RELATIONS IN THE COMBINATION OF PENTYLENETETRAZOLE AND TRIMETHADIONE

S. LOEWE 1, R. A. ALDOUS 1, S. R. FOX 1, D. G. JOHNSON 1, and W. PERKINS 1

1 Department of Pharmacology, University of Utah College of Medicine, Salt Lake City, Utah

The combined action of trimethadione and pentylenetetrazole was studied by determining, for six endpoints, the combined doses required for equieffectiveness; this was accomplished by experimentally establishing the course of the isobols of these endpoint effects.

The endpoints, determined in terms of median effective doses, were: threshold seizure, generalized clonic seizure, tonic extensor seizure, ejaculation, neurotoxicity, and death.

The field of combined doses studied extended up to 1.25 times the median neurotoxic dose of trimethadione and up to 1.75 times the LD50 of pentylenetetrazole.

Whereas the neurotoxicity of trimethadione was not significantly modified by pentylenetetrazole, the five other effects, despite their heterogeneity, were found to be all about equally antagonized by trimethadione.

The details of the interrelation between the combined actions, disclosed by this study, and the advantages of and requirements for the multiple isobolographic procedure employed are discussed.

Submitted on December 27, 1954




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
H. R. Vinik, E. L. Bradley Jr., and I. Kissin
Isobolographic Analysis of Propofol-Thiopental Hypnotic Interaction in Surgical Patients
Anesth. Analg., March 1, 1999; 88(3): 667 - 667.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.