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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 4, 470-474, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE ROLE OF THE LIVER IN THE DISPOSITION OF PROCAINE IN THE DOG

C. W. WHITE JR. 1, EARL H. DEARBORN 1, and E. D. SWISS 1

1 Department of Pharmacology, Boston University School of Medicine, Boston , Massachusetts

Two methods of studying in vivo the effects of the liver in drug disposition have been applied to the study of procaine disposition in the dog.

In agreement with the previous indirect or in vitro experiments in various species, the application of these methods has shown that the liver is important in both the destruction and storage of procaine in the dog in vivo.

Submitted on December 22, 1954






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