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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 4, 421-430, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

ANTERIOR CHAMBER INJECTION IN THE RABBIT AS A METHOD FOR DETERMINING IRRITANCY OF LOCAL ANESTHETICS

ROBERT W. SPENCER 1, HAROLD G. SCHEIE 1, and ROBERT D. DRIPPS 1

1 Departments of Ophthalmology and Anesthesiology, Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia

Injection of local anesthetic drugs into the anterior chamber of the rabbit eye is presented as a method for determining the irritant properties of these substances. Results with this method correlate well with the trypan blue test and with results obtained in man.

Submitted on December 22, 1954






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.