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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 4, 414-420, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

ALCOHOL ON THE CORONARY CIRCULATION OF THE DOG

NORMAN LASKER 1, THEODORE R. SHERROD 1, and KEITH F. KILLAM 1

1 Department of Pharmacology, University of Illinois College of Medicine, Chicago 12, Iflinoi

The effects of ethyl alcohol on coronary blood flow were studied in the openchest dog anesthetized with pentobarbital sodium.

1. The rapid intravenous administration of 375 and 500 mgm./kgm. of ethanol produced a marked increase in coronary sinus outflow and coronary arterial inflow.

2. The slow intravenous infusion of a 10 per cent solution of ethanol over a 35 minute period or until a total dose of 500 mgm./kgm. was given resulted in a 30 per cent increase in coronary sinus outflow.

3. Ethyl alcohol was less effective than aminophylline and papaverine hydrochloride on close arterial injection into the circumflex branch of the left coronary artery.

Submitted on December 20, 1954






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