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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 4, 383-392, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

RENAL AND CARDIOVASCULAR HEMODYNAMIC RESPONSE TO GANGLIONIC BLOCKADE WITH PENDIOMIDE AND A COMPARISON WITH HEXAMETHONIUM AND ARFONAD

JOHN H. MOYER 1 and CARROLL A. HANDLEY 1

1 Departments of Pharmacology and Medicine, Baylor University College of Medicine, Houston, Texas

Pendiomide in doses of 6 to 12 mgm./kgm. produces adequate ganglionic blockade to block the transmission of electrical stimuli along the vagus nerve. In this dosage range in dogs, Pendiomide is a relatively effective hypotensive agent. When Pendiomide is given in this concentration, renal vascular resistance decreases and renal blood flow, glomerular filtration rate, and the excretion of water and electrolytes are not altered appreciably.

If glomerular filtration rate is depressed following ganglionic blockade and blood pressure reduction, norepinephrine will increase the blood pressure and return glomerular filtration rate towards the control values. This is usually associated with an increase in sodium and water excretion.

Submitted on November 5, 1954




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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.