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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 4, 376-382, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

BLOOD LEVEL STUDIES OF C14-DIGITOXIN IN HUMAN SUBJECTS WITH CARDIAC FAILURE

GEORGE T. OKITA 1, PETER J. TALSO 1, JOHN H. CURRY JR. 1, FREDERICK D. SMITH JR. 1, and E. M. K. GEILING 1

1 Department of Pharmacology, the Department of Medicine, and the Argonne Cancer Research Hospital, The University of Chicago; Department of Medicine, Loyola University School of Medicine, Chicago

Using biosynthetically labeled C14 digitoxin, quantitative detection of micro amounts of unchanged digitoxin and its degradation products was accomplished. By the addition of non-labeled carrier digitoxin to the extraction mixture it is possible to isolate as little as 0.02 microgm. of radioactive digitoxin per sample of blood. Data have been presented on the blood level concentration, persistence and rate of disappearance of digitoxin from the blood stream of eight cardiac patients.

Submitted on October 16, 1954




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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.