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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 3, 353-358, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE EXCRETORY PRODUCTS OF LANATOSIDE C AND DIGITOXIN IN THE RAT

B. T. BROWN 1, DOROTHY RANGER 1, and S. E. WRIGHT 1

1 Department of Pharmacology, University of Sydney, Sydney, Australia

The cardio-active urinary excretory products of lanatoside C and digitoxin in rat urine have been studied by the use of paper chromatography and estimated quantitatively by the embryonic chick heart method.

Unchanged lanatoside C is excreted in the first 24 hours to the extent of about 7.5 per cent of the administered dose (1 microgm./gm. of body weight). When larger doses are given, free digoxin and a cardio-active metabolite previously found in rat urine after digoxin administration also appear.

Very little unchanged digitoxin is excreted in rat urine, but a metabolite which is not digitoxigenin, but which apparently has lower biological activity than digitoxin is present in the first 24 hours' urine excretion.

Submitted on December 3, 1954






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.