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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 3, 341-352, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE SYMPATHOMIMETIC AND OTHER PHARMACOLOGICAL PROPERTIES OF DL 2-(1 ,2 ,3 ,4-TETRAHYDRO-1-NAPHTHYL)-IMIDAZOLINE (TETRAHYDROZOLINE)

D. E. HUTCHEON 1, S. Y. P'AN 1, J. F. GARDOCKI 1, and DORIS A. JAEGER 1

1 Research Laboratories, Chas. Pfizer & Co., Inc., Brooklyn, N. V.

Tetrahydrozoline (dl 2-(1 ,2 ,3 ,4-tetrahydro-1-naphthyl)-imidazoline) was found to be an active vasoconstrictor with pressor activity of a relatively prolonged duration.

Other sympathomimetic properties of the compound included its ability (1) to cause a long-lasting contraction of the nictitating membrane, (2) to inhibit the tone and rhythm of the intestine and (3) to increase the blood sugar.

Tetrahydrozoline, in contrast to amphetamine, prolonged the sleeping time of mice under pentobarbital anesthesia.

In rats and mice tetrahydrozoline was less toxic than naphazoline. Its toxicity also showed less variability between species. Tetrahydrozoline had a low degree of local toxic action measured by its effect On the conjunctiva and on ciliary movement of the tracheal mucosa.

Submitted on December 2, 1954




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W. M. GRANT
OPHTHALMIC PHARMACOLOGY AND TOXICOLOGY
Arch Ophthalmol, August 1, 1956; 56(2): 299 - 316.
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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.