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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 3, 310-318, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF LEVALLORPHAN TARTRATE, NALORPHINE HCl AND WIN 7681 (1-ALLYL-4-PHENYL-4-CARBETHOXYPIPERIDINE) ON RESPIRATORY DEPRESSION AND ANALGESIA INDUCED BY SOME ACTIVE ANALGETICS

P. J. COSTA 1 and D. D. BONNYCASTLE 1

1 Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut

In experiments in rats in which levallorphan, nalorphine and WIN 7681 were tested against the respiratory depressant action of levo-Dromoran, levomethadone, morphine, meperidine and alphaprodine, it was found that while all possessed some ability to restore depressed respiration to normal, levallorphan was the most active.

Some indications of specificity of action were observed, and these are discussed briefly.

Submitted on November 9, 1954






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.