JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 3, 299-309, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

INHIBITION OF THE APOMORPHINE-INDUCED VOMITING SYNDROME BY ANTIHISTAMINIC AGENTS

ELDON M. BOYD 1, WILFRED A. CASSELL 1, CARL E. BOYD 1, and JOAN K. MILLER 1

1 Department of Pharmacology, Queen's University, Kingston, Ontario, Canada

1. In dogs, two-thirds of 31 antihistaminic agents significantly inhibited vomiting in the stringent apomorphine-challenge.

2. The antemetic doses were one-tenth to one-half or higher of the minimal toxic dose.

3. Fifty-seven to 75 per cent of the results by apomorphine-assay agreed with results in an antimotionsickness assay.

4. Analysis of antemeticostructural assignations suggested that antemetic agents may be found with a higher therapeutic index.

Submitted on November 6, 1954






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.