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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 3, 292-298, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF 2,2-DIETHYL 1,3-PROPANEDIOL AND 2,3-DIETHYL 1,4-BUTANEDIOL ON THE SUCCINOXIDASE SYSTEM

HAROLD A. NEUFELD 1, LEONARD J. GREENBERG 1, and IRWIN H. SLATER 1

1 The Department of Biochemistry and the Division of Pharmacology, Department of Radiation Biology, The University of Rochester, School of Medicine and Dentistry, Rochester, N. Y.

The effects of DEB and DEP on the succinoxidase system have been studied.

DEB inhibited the entire succinoxidase system by interfering with the rates of oxidation and reduction of cytochrome c but was without effect on succinic dehydrogenase.

DEP had no effect on the cytochrome portion of the succinoxidase system but did inhibit a partially purified preparation of succinic dehydrogenase.

Submitted on November 1, 1954






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.