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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 2, 241-249, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

A POLAROGRAPHIC STUDY OF MERSALYL (SALYRGAN)-THIOL COMPLEXES AND OF THE EXCRETED PRODUCTS OF MERSALYL

I. M. WEINER 1 and OTTO H. MULLER 1

1 Department of Physiology, State University of New York, Upstate Medical Center, Syracuse 10, New York

The relationship between the half-wave potential of the first polarographic wave and pH has been described for Salyrgan-cysteine, Salyrgan-glutathione, Salyrgan-thioglycolic acid and the excretion products of Salyrgan. The urinary mercurial resembles Salyrgan-cysteine in this respect.

A correlation between the excretion of mercury and neutral sulfur has been established. It has been shown that a compound behaving polarographically like Salyrgan can be obtained from the urinary mercurial by a procedure which precipitates sulfhydryl compounds. This evidence indicates that Salyrgan is excreted in a complex with one or more thiols of low molecular weight. Little if

any mercury appears in the urine in another form during the first three hours after Salyrgan administration.

The excreted Salyrgan-thiol complex is considered to be a detoxication product.

Submitted on September 20, 1954






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.