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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 2, 238-240, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

A PHARMACOLOGICAL COMPARISON OF THE OPTICAL ISOMERS OF 5-ETHYL-5-METHYL-2,4-OXAZOLIDINEDIONE AND OF 3,5- DIMETHYL - 5 - ETHYL - 2,4 - OXAZOLIDINEDIONE (PARAMETITADIONE, PARADIONE)

THOMAS C. BUTLER 1 and WILLIAM J. WADDELL 1

1 Department of Pharmacology University of North Carolina School of Medicine, Chapel Hill, North Carolina

In anesthetic activity in mice no significant difference was found between the optical isomers of paramethadione or between the optical isomers of 5-ethyl- 5-methyl-2 , 4-oxazolidinedione ("EMO").

No significant difference was found between the optical isomers of EMO in their apparent volumes of distribution or in their rates of elimination in mice.

The dextrorotatory isomer of paramethadione is demethylated by the mouse about 15 per cent more rapidly than is the antipodal form.

Submitted on October 26, 1954






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