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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 2, 228-237, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

ANTIHISTAMINICS AS EPINEPHRINE SENSITIZERS

KANAME KURIAKI 1 and TOHORU UCHIDA 1

1 Department of Pharmacology, Kurume University Medical College, Fukuoka-ken, Japan

The antihistaminics, Benadryl and Diatrin, sensitize peripheral organs to epinephrine as well as to sympathetic stimulation. In addition, these agents inhibit amine oxidase activity.

The antihistaminic, Anergen, does not inhibit amine oxidase and its effects on effector sites responding to epinephrine and sympathetic stimulation are variable.

Submitted on October 22, 1954






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Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.