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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 2, 200-205, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE VASODEPRESSOR RESPONSE OF FLUORINE ADMINISTERED ORALLY TO DOGS

ALFRED W. RICHARDSON 1, JOSEPH C. MUHLER 1, and JACK G. BISHOP 1

1 Department of Physiology, School of Medicine and Department of Chemistry, University of Indiana, Bloomington, Indiana

The oral administration of 5 mgm. of fluorine as sodium fluoride or stannous fluoride resulted in hypotension. Sodium fluoride containing 1 mgm. of fluorine, the amount orally ingested daily by the average person from a communal water supply containing 1.0 ppm, did not elicit a hypotensive response. In the conditions where sufficient fluorine was administered to alter the blood pressure, there were changes in the heart rate, pulse pressure and blood flow as would be expected with a hypotensive agent. Stannous fluoride elicited also a decline in the rectal and gastrocnemius muscle temperatures.

We wish to acknowledge the technical assistance of Patricia A. Doane and James C. Walker during these studies.

Submitted on October 2, 1954






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