OBSERVATIONS ON THE FATE OF DROMORAN IN THE DOG AND ITS SECRETION INTO THE GASTRIC JUICE

¹ Laboratory of Chemical Pharmacology; Laboratory of Kidney and Electrolyte Metabolism, National Heart Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland

A method is described for the estimation of l- and d-Dromoran in biological material.

After intravenous injection in the dog, both l- and d-Dromoran are rapidly and virtually completely metabolized. The duration of action of l-Dromoran is prolonged far beyond the time when appreciable amounts of unchanged drug remain in the body. Both isomers are largely metabolized to conjugates of the parent drug but considerable amounts of the compound are metabolized along unknown pathways. Neither isomer is converted to the demethylated derivative by the intact animal or in vitro by a demethylating enzyme system present in liver.

After the intravenous administration of l- or d-Dromoran, concentrations of the drugs many times that of plasma are secreted into the gastric juice.