JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by PETERS, L.
Right arrow Articles by KANDEL, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PETERS, L.
Right arrow Articles by KANDEL, A.
Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 2, 148-159, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

INHIBITION OF THE RENAL TUBULAR EXCRETION OF N'-METHYLNICOTINAMIDE (NMN) BY SMALL DOSES OF A BASIC CYANINE DYE

LAWRENCE PETERS 1, KEVIN J. FENTON 1, MARY L. WOLF 1, and ALEXANDER KANDEL 1

1 Department of Pharmacology, School of Medicine, Western Reserve University, Cleveland, Ohio; Department of Pharmacology, Tulane University Medical School, New Orleans, Louisiana

Single intravenous injections of a basic cyanine dye into dogs, in amounts ranging from 1.25 to 12.5 micromoles/kgm., produced a marked and prolonged inhibition of the renal tubular excretion of N'-methylnicotinamide (NMN). The renal excretion characteristics of creatinine, p-aminohippurate and glucose were not altered under these conditions. In an earlier study, larger doses of the cyanine (25 or more micromoles/kgm.) frequently produced renal tubular injury with nonspecific, generalized, renal functional impairment.

Speculation concerning the mechanism of the inhibition of NMN excretion, and its significance for further studies of the renal tubular transport system involved, are discussed.

Submitted on September 16, 1954




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. E. Busch, S. Quester, J. C. Ulzheimer, S. Waldegger, V. Gorboulev, P. Arndt, F. Lang, and H. Koepsell
Electrogenic Properties and Substrate Specificity of the Polyspecific Rat Cation Transporter rOCT1
J. Biol. Chem., December 20, 1996; 271(51): 32599 - 32604.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1955 by the American Society for Pharmacology and Experimental Therapeutics.