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Journal of Pharmacology And Experimental Therapeutics, Vol. 113, Issue 1, 115-123, 1955
Copyright © 1955 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF ADRENERGIC SUBSTANCES AND ISCHEMIA ON THE BLOOD FLOW AND PERIPHERAL RESISTANCE OF THE CANINE MESENTERIC VASCULAR BED BEFORE AND DURING ADRENERGIC BLOCKADE

Harold D. Green 1, C. P. Deal Jr. 1, Suthip Bardhanabaedya 1, and Adam B. Denison Jr. 1

1 Department of Physiology and Pharmacology of The Bowman Gray School of Medicine of Wake Forest College, Winston-Salem, North Carolina

Blood flow in the cranial mesenteric artery was measured with an electromagnetic flowmeter during intra-arterial injections of 1.0, 3.0, and 10.0 micrograms of l-epinephrine (EPI), l-norepinephrine (NOR), and isopropylnorepinephrine (ISO), and prior to and following one-minute periods of ischemia.

These observations were recorded during the control state and after the establishment of various levels of adrenergic blockade which were created by the intra-arterial injections of logarithmically increasing doses of Ilidar, ranging from 0.1 to 100 mgm.

In the control state EPI and NOR induced vasoconstriction which was comparable to that seen in the skeletal muscle and skin vascular beds, but greater than that seen in the renal vascular beds. ISO caused only pure vasodilation. Ischemia induced a mild and somewhat inconsistent reactive hyperemia.

During adrenergic blockade there was a mild but significant reversal of the response to EPI. The NOR constrictor responses were progressively abolished along with the secondary vasodilator responses, and only insignificant reversals (primary vasodilator responses) were noted. Vasodilator responses to ISO and ischemia were reduced but not fully abolished by the highest dose of Ilidar used (100 mgm.)

On the basis of the above responses, it appears that the mesenteric vascular bed is qualitatively different from the cutaneous and renal vascular beds and is qualitatively similar to but quantitatively less reactive than the skeletal muscle vascular beds.

Submitted on September 8, 1954




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