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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 4, 484-494, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLISM AND CONTRACTION OF CAT HEART MUSCLES AS AFFECTED BY DRUGS

Kwang Soo Lee 1

1 Department of Pharmacology, Jefferson Medical College, Philadelphia 7, Pa.

The oxygen consumption of papillary muscles increased following activity and this increase was proportional to the rate of stimulation with frequencies up to sixty per minute.

Iodoacetate and fluoroacetate appear to inhibit the contraction of the muscle by interfering with the metabolism of the muscle thus decreasing the energy available for contraction.

The lack of energy available following the impairment of the metabolic pathways in poisoned muscles is manifested in the staircase phenomenon of the muscles.

Dinitrophenol increases oxygen consumption while decreasing the contractility of the muscle.

Submitted on August 26, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.