JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 4, 473-479, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

ENHANCEMENT OF THE ACTION OF CERTAIN ANALGETIC DRUGS BY beta-DIETHYLAMINOETHYLDIPHENYLPROPYLACETATE HYDROCHLORIDE

Leonard Cook 1, Geraldine Navis 1, and Edwin J. Fellows 1

1 Research and Development Division, Smith, Kline and French Laboratories, Philadelphia, Pennsylvania

The analgetic action of methadone, meperidine, morphine, codeine, and methorphinan was enhanced by SKF No. 525-A in rats. This compound, however, did not significantly alter the LD50's of morphine or meperidine in rats. Furthermore, SKF No. 525-A did not increase the respiratory depressant action of morphine. SKF No. 525-A enhanced the potency of morphine in tolerant animals; however, it was shown that rats developed tolerance to SKF No. 525-A plus morphine in a manner comparable to morphine alone.

Submitted on August 18, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.