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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 4, 404-412, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

SOME EFFECTS OF N-METHYL-ALPHA-PHENYLSUCCINIMIDE (MILONTIN) ON THE CENTRAL NERVOUS SYSTEM

William H. Funderburk 1 and Roscoe T. Woodcock 1

1 Traverse City State Hospital, Traverse City, Michigan

The effects of Milontin have been studied at various levels of the cerebrospinal axis and compared with the effects of trimethadione.

1. Neither of these drugs, in doses which have effects elsewhere in the central nervous system, have a demonstrable effect at the spinal level. The patellar reflex itself and the effects on this reflex of stimulating the sciatic nerves are unchanged by these drugs.

2. Milontin has a mild sedative action similar to that of trimethadione as shown by the appearance of sleep spindles in the EEG and by the reduction of the arousal response elicited by stimulating the activating center following the administration of adequate amounts of the drug.

3. While Milontin and trimethadione are apparently equipotent in certain depressant actions unrelated to seizure activity, Milontin is more potent than trimethadione in suppressing cortical after-discharge.

Submitted on July 2, 1954






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