THE ANALEPTIC ACTION OF 1-n-BUTYLAMINO-3-p-TOLUIDINO-2-PROPANOL (W181) IN SLEEP OR PARALYSIS PRODUCED BY CERTAIN CENTRAL NERVOUS SYSTEM DEPRESSANTS

¹ Wallace Laboratories, Division of Carter Products, Inc., New Brunswick, New Jersey

Experiments were carried out to determine the ability of W181 (l-n-butyl-amino-3-p-toluidino-2-propanol) to shorten anesthesia or paralysis produced by some well known central depressant drugs.

Arousal from phenobarbital, mephenesin and benzimidazole depression could be obtained with non-convulsant doses of W181. In pentobarbital or hexobarbital anaesthesia doses of the order of two LD₅₀ of W181 were required to produce significant shortening of anesthesia. With chloral hydrate and thiopental even larger doses were necessary to produce awakening. The significance of the finding is discussed.