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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 4, 393-398, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF PHOSPHORYLATED HESPERIDIN ON BLOOD COAGULATION

Renê Bourgain 1, Cecil Symons 1, Margaret Todd 1, and Irving S. Wright 1

1 Department of Medicine, The New York Hospital-Cornell University Medical College, New York 21, N. Y.

The action of P. H. on the blood coagulation mechanism was studied in rabbits and its anticoagulant activity described.

Recalcification times after intravenous injection of 100-150 mgm. P.H./kgm. body weight were consistently prolonged, and antithrombin activity was observed.

Hypocoagulability of the blood induced by P.H. was neutralized by the intravenous injection of protamine.

P. H. probably affects the last stage of the blood clotting mechanism and in this property has a similar action to heparin.

Acknowledgment is made to Mr. William Swain of the National Drug Company for supplying phosphorylated hesperidin.

We are grateful to Miss Lorraine Herzig for technical help and to Dr. Erwin Sheppard for constructive advice and criticism.

Submitted on June 21, 1954






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