JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow A correction has been published
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cook, L.
Right arrow Articles by Fellows, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cook, L.
Right arrow Articles by Fellows, E. J.
Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 3, 382-386, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF beta-DIETHYLAMINOETHYLDIPHENYLPROPYLACETATE HYDROCHLORIDE ON THE ACTION OF A SERIES OF BARBITURATES AND C.N.S. DEPRESSANTS

Leonard Cook 1, Edward Macko 1, and E. J. Fellows 1

1 Development Division, Smith, Kline and French Laboratories, Philadelphia, Pennsylvania

Pretreatment with SKF No. 525-A prolonged the hypnotic action of secobarbital, pentobarbital, hexobarbital, amobarbital, butethal, Ortal, phenobarbital and chloral hydrate. On the other hand, the hypnotic action of barbital, thioethamyl, thiopental and methylparafynol was not prolonged by pretreatment with SKF No. 525-A. Thus, it is apparent that SKF No. 525-A exhibited a certain degree of selectivity insofar as the agents which it potentiates are concerned.

Submitted on August 18, 1954




This article has been cited by other articles:


Home page
 Drug Metab. Dispos.Home page
P. J. Murphy
The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 1, 1909-1958
Drug Metab. Dispos., January 1, 2008; 36(1): 1 - 5.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.