JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 3, 378-381, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE RELATION BETWEEN THE STRUCTURE OF HALOGENATED BENZOIC ACIDS AND THE DEPLETION OF ADRENAL ASCORBIC ACID CONTENT

J. Maxwell Little 1, Eugene R. Strader 1, and Edward B. Truitt Jr. 2

1 Laboratories of the A. H. Robins Co., Inc., The Department of Physiology and Pharmacology, The Bowman Gray School of Medicine of Wake Forest College, Winston-Salem, N. C.
2 Laboratories of the A. H. Robins Co., Inc. and the Department of Physiology and Pharmacology, The Bowman Gray School of Medicine of Wake Forest College, Winston-Salem, N. C.

Benzoic acid, with an intraperitoneal dose of 1.86 mM/kgm., will result in a significant depletion of adrenal ascorbic acid in the rat measured two hours later. Substitution of an o-hydroxyl group in the benzoic acid ring enhances the activity in equimolar doses. Substitution of a halogen in the ortho position removes the activity. However, substitution of a halogen in meta or para positions enhances the activity in doses equimolar to benzoic acid. An exception to this is fluorine which appears not to affect significantly the activity of benzoic acid when substituted in the meta or para positions.

Some possible explanations of the structure-function relationship are discussed, but a satisfactory explanation seems not to he available as yet.

Submitted on August 13, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.