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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 3, 364-373, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF MEPHENTERMINE ON HYPODYNAMIC AND ARRHYTHMIC ISOLATED FROG HEARTS

Jerome M. Glassman 1 and Joseph Seifter 1

1 Wyeth Institute of Applied Biochemistry, Philadelphia, Pa.

Mephentermine was studied on the isolated, perfused frog heart and compared with epinephrine, l-norepinephrine, amphetamine, d-desoxyephedrine and 1-ephedrine. Mephentermine was found to be more potent than any of these for restormg the contractility of the depressed or hypodynamic heart; moreover, in simultaneous perfusion studies it was effective in preventing or terminating epinephrine arrhythmia both in the dynamic and hypodynamic preparation.

Submitted on August 6, 1954






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