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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 3, 326-340, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE ORIGIN OF STREPTOMYCIN-DEPENDENT VARIANTS OF ESCHERICHIA COLT

Avram Goldstein 1

1 Department of Pharmacology, Harvard Medical School, Boston

It has been demonstrated beyond reasonable doubt that the initial step in the origin of streptomycin dependence in Escherichia coli is a mutation that occurs in the complete absence of streptomycin. These mutants must undergo further changes of a mutational or adaptive nature in the presence of streptomycin, before they can give rise to streptomycin-dependent colonies.

Submitted on July 13, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.